Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

被引：33

作者：

Zheng, Huidong ^{[3
]}

Huang, Yuanyuan ^{[3
]}

Wang, Zhiwei ^{[3
]}

Li, Huaifeng ^{[1
,2
]}

Huang, Kuo-Wei ^{[1
,2
]}

Yuan, Yaofeng ^{[3
]}

Weng, Zhiqiang ^{[3
]}

机构：

[1] King Abdullah Univ Sci & Technol, KAUST Catalysis Ctr, Thuwal 239556900, Saudi Arabia

[2] King Abdullah Univ Sci & Technol, Div Chem & Life Sci & Engn, Thuwal 239556900, Saudi Arabia

[3] Fuzhou Univ, Coll Chem & Chem Engn, Fuzhou 350108, Fujian, Peoples R China

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 49期

基金：

中国国家自然科学基金;

关键词：

Copper catalysis; Trifluoromethylated acetylenes; Trifluoromethylation; Alkynyltrifluoroborates; ARYL BORONIC ACIDS; TERMINAL ALKYNES; INTERNAL ALKYNES; CHEMISTRY; REAGENT;

D O I：

10.1016/j.tetlet.2012.09.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed. (c) 2012 Published by Elsevier Ltd.

引用

页码：6646 / 6649

页数：4

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