Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

被引：33
|
作者：
Zheng, Huidong [3 ]
Huang, Yuanyuan [3 ]
Wang, Zhiwei [3 ]
Li, Huaifeng [1 ,2 ]
Huang, Kuo-Wei [1 ,2 ]
Yuan, Yaofeng [3 ]
Weng, Zhiqiang [3 ]
机构：
[1] King Abdullah Univ Sci & Technol, KAUST Catalysis Ctr, Thuwal 239556900, Saudi Arabia
[2] King Abdullah Univ Sci & Technol, Div Chem & Life Sci & Engn, Thuwal 239556900, Saudi Arabia
[3] Fuzhou Univ, Coll Chem & Chem Engn, Fuzhou 350108, Fujian, Peoples R China
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 49期
基金：
中国国家自然科学基金;
关键词：
Copper catalysis; Trifluoromethylated acetylenes; Trifluoromethylation; Alkynyltrifluoroborates; ARYL BORONIC ACIDS; TERMINAL ALKYNES; INTERNAL ALKYNES; CHEMISTRY; REAGENT;
D O I：
10.1016/j.tetlet.2012.09.083
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed. (c) 2012 Published by Elsevier Ltd.
引用
收藏
页码：6646 / 6649
页数：4
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