Photoinactivation with Novel Porphyrin Derivatives: An in Vitro Study on Multi-drug Resistant Escherichia coli

被引：0
|
作者：
Akbiyik, Ayse [1 ]
Tasli, Huseyin [1 ]
Topaloglu, Nermin [2 ]
Alptuzun, Vildan [3 ]
Parlar, Sulunay [3 ]
机构：
[1] Ege Univ, Eczacil Fak, Farmasotuk Mikrobiyol, Ananbilim Dali, Izmir, Turkey
[2] Izmir Katip Celebi Univ, Muhendisl & Mimarl Fak, Biyomed Muhendisli Bolumu, Izmir, Turkey
[3] Ege Univ, Eczacil Fak, Farmasotuk Kimya Ananbilim Dali, Izmir, Turkey
来源：
2017 MEDICAL TECHNOLOGIES NATIONAL CONGRESS (TIPTEKNO) | 2017年
关键词：
antimicrobial photodynamic therapy; porphyrin; multiple drug resistance; Escherichia coli; ANTIMICROBIAL ACTIVITY;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In the study, it was aimed to investigate the bactericidal activity of antimicrobial photodynamic therapy (aPDT) performed on in-vitro conditions with novel cationic-porphyrin derivatives (CPDs) on multidrug resistant E. coli. In aPDT experiments performed with different concentrations of photosensitizer and different energy densities, 99.9999% or more decrease in bacterial survival was detected. aPDT carried out with CPDs at concentrations below the MIC values has the potential to display a strong antimicrobial activity against the MDR E. coli clinical isolates.
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页数：4
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