Photoinactivation with Novel Porphyrin Derivatives: An in Vitro Study on Multi-drug Resistant Escherichia coli

被引：0

作者：

Akbiyik, Ayse ^{[1
]}

Tasli, Huseyin ^{[1
]}

Topaloglu, Nermin ^{[2
]}

Alptuzun, Vildan ^{[3
]}

Parlar, Sulunay ^{[3
]}

机构：

[1] Ege Univ, Eczacil Fak, Farmasotuk Mikrobiyol, Ananbilim Dali, Izmir, Turkey

[2] Izmir Katip Celebi Univ, Muhendisl & Mimarl Fak, Biyomed Muhendisli Bolumu, Izmir, Turkey

[3] Ege Univ, Eczacil Fak, Farmasotuk Kimya Ananbilim Dali, Izmir, Turkey

来源：

2017 MEDICAL TECHNOLOGIES NATIONAL CONGRESS (TIPTEKNO) | 2017年

关键词：

antimicrobial photodynamic therapy; porphyrin; multiple drug resistance; Escherichia coli; ANTIMICROBIAL ACTIVITY;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In the study, it was aimed to investigate the bactericidal activity of antimicrobial photodynamic therapy (aPDT) performed on in-vitro conditions with novel cationic-porphyrin derivatives (CPDs) on multidrug resistant E. coli. In aPDT experiments performed with different concentrations of photosensitizer and different energy densities, 99.9999% or more decrease in bacterial survival was detected. aPDT carried out with CPDs at concentrations below the MIC values has the potential to display a strong antimicrobial activity against the MDR E. coli clinical isolates.

引用

页数：4

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