The paradoxical role of IL-17 in atherosclerosis

被引：71
|
作者：
Gong, Fangchen [1 ]
Liu, Zhengxia [1 ]
Liu, Jingning [1 ]
Zhou, Ping [1 ]
Liu, Ying [1 ]
Lu, Xiang [1 ]
机构：
[1] Nanjing Med Univ, Dept Geriatr, Affiliated Hosp 2, Nanjing 210029, Jiangsu, Peoples R China
来源：
CELLULAR IMMUNOLOGY | 2015年 / 297卷 / 01期
基金：
美国国家科学基金会;
关键词：
Atherosclerosis; IL-17; Coronary artery disease; Immunity; DELTA-T-CELLS; ROR-GAMMA-T; SMOOTH-MUSCLE-CELLS; C-REACTIVE PROTEIN; NF-KAPPA-B; MONOCLONAL-ANTIBODY; IMMUNE-RESPONSES; TH17; CELLS; TNF-ALPHA; DIFFERENTIATION;
D O I：
10.1016/j.cellimm.2015.05.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Atherosclerosis is a chronic inflammatory disease mediated by innate and adaptive immune responses. In recent years, CD4(+) T cells (Th1, Th2, Treg, and Th17) have been increasingly studied for their role in atherosclerosis pathophysiology, atheroma stability, plaque rupture, and life-threatening acute coronary syndrome. IL-17, a marker cytokine of Th17 cells, has been reported to be involved in the pathogenesis of rheumatoid arthritis, inflammatory bowel disease, and asthma. However, its role in atherosclerosis has been poorly characterized. This article provides a comprehensive overview of the role of IL-17 in the development of atherosclerosis and human coronary artery diseases. (C) 2015 Published by Elsevier Inc.
引用
收藏
页码：33 / 39
页数：7
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