Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats

被引：98
|
作者：
Kompagne, Hajnalka [2 ]
Bardos, Gyoergy [1 ]
Szenasi, Gabor [2 ]
Gacsalyi, Istvan [2 ]
Harsing, Laszlo G. [2 ]
Levay, Gyoergy [2 ]
机构：
[1] Eotvos Lorand Univ, Inst Biol, Dept Physiol & Neurobiol, H-1117 Budapest, Hungary
[2] EGIS Pharmaceut Plc, Dept Preclin Res, Budapest, Hungary
来源：
BEHAVIOURAL BRAIN RESEARCH | 2008年 / 193卷 / 02期
关键词：
anhedonia; anxiety-related behaviour; chronic mild stress; depression; rat; social avoidance;
D O I：
10.1016/j.bbr.2008.06.008
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
A 3-week chronic mild stress (CMS) protocol decreased sucrose preference of rats and increased immobility in the forced swim test. It also induced social avoidance and increased grooming, but acted as if reducing anxiety in the plus-maze. Sucrose preference and social avoidance, but not other measures of the behaviour, showed significant correlation. We conclude that CMS-induced depression-like behaviour is associated with social avoidance, a seemingly anxiety-related measure, but not with other anxiety-like traits in rats. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：311 / 314
页数：4
相关论文
共 50 条
  • [31] Chronic physical exercise reduces anxiety-like behavior in rats
    Fulk, LJ
    Stock, HS
    Lynn, A
    Marshall, J
    Wilson, MA
    Hand, GA
    INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2004, 25 (01) : 78 - 82
  • [32] EFFECTS OF PRENATAL ALCOHOL EXPOSURE AND ADOLESCENT CHRONIC MILD STRESS ON ANXIETY- AND DEPRESSIVE-LIKE BEHAVIORS IN ADOLESCENT RATS
    Raineki, C.
    Chew, L.
    Holman, P. J.
    Comeau, W.
    Weinberg, J.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2012, 36 : 275A - 275A
  • [33] Antibiotics exposure attenuates chronic unpredictable mild stress-induced anxiety-like and depression-like behavior
    Meng, Chen
    Feng, Siyuan
    Hao, Zikai
    Dong, Chen
    Liu, Hong
    PSYCHONEUROENDOCRINOLOGY, 2022, 136
  • [34] The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress
    Sachs, Benjamin D.
    Rodriguiz, Ramona M.
    Siesser, William B.
    Kenan, Alexander
    Royer, Elizabeth L.
    Jacobsen, Jacob P. R.
    Wetsel, William C.
    Caron, Marc G.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2013, 16 (09): : 2081 - 2094
  • [35] Chronic-stress induced modulation of different states of anxiety-like behavior in female rats
    Mitra, R
    Vyas, A
    Chatterjee, G
    Chattarji, S
    NEUROSCIENCE LETTERS, 2005, 383 (03) : 278 - 283
  • [36] Modulation of different states of anxiety-like behavior by chronic stress
    Vyas, A
    Chattarji, S
    BEHAVIORAL NEUROSCIENCE, 2004, 118 (06) : 1450 - 1454
  • [37] Histaminergic system of the lateral septum in the modulation of anxiety-like behaviour in rats
    Rostami, P.
    Zarrindast, M. R.
    Valizadegan, F.
    Rezayof, A.
    EUROPEAN JOURNAL OF NEUROLOGY, 2008, 15 : 213 - 213
  • [38] Histaminergic system of the lateral septum in the modulation of anxiety-like behaviour in rats
    Zarrindast, Mohammad-Reza
    Valizadegan, Farhad
    Rostami, Parvin
    Rezayof, Ameneh
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 583 (01) : 108 - 114
  • [39] Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats
    Martín-García, E
    Pallarès, M
    BEHAVIOURAL BRAIN RESEARCH, 2005, 164 (01) : 117 - 127
  • [40] Chronic unpredictable mild stress generates oxidative stress and systemic inflammation in rats
    Laura Lopez-Lopez, Ana
    Bonilla Jaime, Herlinda
    Escobar Villanueva, Maria del Carmen
    Brianza Padilla, Malinalli
    Vazquez Palacios, Gonzalo
    Alarcon Aguilar, Francisco Javier
    PHYSIOLOGY & BEHAVIOR, 2016, 161 : 15 - 23
12345