Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats

被引：98

作者：

Kompagne, Hajnalka ^{[2
]}

Bardos, Gyoergy ^{[1
]}

Szenasi, Gabor ^{[2
]}

Gacsalyi, Istvan ^{[2
]}

Harsing, Laszlo G. ^{[2
]}

Levay, Gyoergy ^{[2
]}

机构：

[1] Eotvos Lorand Univ, Inst Biol, Dept Physiol & Neurobiol, H-1117 Budapest, Hungary

[2] EGIS Pharmaceut Plc, Dept Preclin Res, Budapest, Hungary

来源：

BEHAVIOURAL BRAIN RESEARCH | 2008年 / 193卷 / 02期

关键词：

anhedonia; anxiety-related behaviour; chronic mild stress; depression; rat; social avoidance;

D O I：

10.1016/j.bbr.2008.06.008

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

A 3-week chronic mild stress (CMS) protocol decreased sucrose preference of rats and increased immobility in the forced swim test. It also induced social avoidance and increased grooming, but acted as if reducing anxiety in the plus-maze. Sucrose preference and social avoidance, but not other measures of the behaviour, showed significant correlation. We conclude that CMS-induced depression-like behaviour is associated with social avoidance, a seemingly anxiety-related measure, but not with other anxiety-like traits in rats. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：311 / 314

页数：4

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