Use of the 2-Chlorotrityl Chloride Resin for Microwave-Assisted Solid Phase Peptide Synthesis

被引：24

作者：

Ieronymaki, Matthaia ^{[1
]}

Androutsou, Maria Eleni ^{[1
,2
]}

Pantelia, Anna ^{[1
]}

Friligou, Irene ^{[1
,2
]}

Crisp, Molly ^{[3
]}

High, Kirsty ^{[3
]}

Penkman, Kirsty ^{[3
]}

Gatos, Dimitrios ^{[1
]}

Tselios, Theodore ^{[1
]}

机构：

[1] Univ Patras, Dept Chem, Rion 26504, Greece

[2] Eldrug SA Pharmaceut Co, Platani 26504, Greece

[3] Univ York, Dept Chem, BioArCh, York YO10 5DD, N Yorkshire, England

来源：

BIOPOLYMERS | 2015年 / 104卷 / 05期

关键词：

solid phase peptide synthesis; microwave assisted peptide synthesis; 2-chlorotrityl chloride resin; racemization; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; SCLEROSIS-LIKE DISEASE; MULTIPLE-SCLEROSIS; BASIC-PROTEIN; IMMUNODOMINANT EPITOPE; AMINO-ACIDS; INDUCTION; LIGANDS;

D O I：

10.1002/bip.22710

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A fast and efficient microwave (MW)-assisted solid-phase peptide synthesis protocol using the 2-chlorotrityl chloride resin and the Fmoc/tBu methodology, has been developed. The established protocol combines the advantages of MW irradiation and the acid labile 2-chlorotrityl chloride resin. The effect of temperature during the MW irradiation, the degree of resin substitution during the coupling of the first amino acids and the rate of racemization for each amino acid were evaluated. The suggested solid phase methodology is applicable for orthogonal peptide synthesis and for the synthesis of cyclic peptides. (C) 2015 Wiley Periodicals, Inc.

引用

页码：506 / 514

页数：9

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