RACEMIZATION-FREE SYNTHESIS OF C-TERMINAL CYSTEINE-PEPTIDE USING 2-CHLOROTRITYL RESIN

被引：0
|
作者：
FUJIWARA, Y [1 ]
AKAJI, K [1 ]
KISO, Y [1 ]
机构：
[1] KYOTO PHARMACEUT UNIV, DEPT MED CHEM, YAMASHINA KU, KYOTO 607, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 03期
关键词：
SOLID PHASE PEPTIDE SYNTHESIS; RACEMIZATION; C-TERMINAL CYSTEINE; BASE TREATMENT; 2-CHLOROTRITYL RESIN; SOMATOSTATIN;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We investigated the effects of bases, resins, and S-protecting groups on the extent of racemization at the C-terminal cysteine during Fmoc-based(Fmoc=fluoren-9-yl-methoxy-carbonyl) solid phase peptide synthesis. The use of 2-chlorotrityl resin was most effective in suppressing the racemization caused by the base treatment for Fmoc-cleavage. Somatostatin was successfully synthesized with practically no racemization using 2-chlorotrityl resin by Fmoc-chemistry.
引用
收藏
页码：724 / 726
页数：3
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