Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis

被引：184
|
作者：
Furue, M. [1 ,2 ,3 ]
Yamamura, K. [1 ,2 ]
Kido-Nakahara, M. [1 ,2 ]
Nakahara, T. [1 ,2 ]
Fukui, Y. [4 ,5 ]
机构：
[1] Kyushu Univ, Dept Dermatol, Grad Sch Med Sci, Fukuoka, Japan
[2] Kyushu Univ, Div Skin Surface Sensing, Grad Sch Med Sci, Fukuoka, Japan
[3] Kyushu Univ, Res & Clin Ctr Yusho & Dioxin, Kyushu Univ Hosp, Fukuoka, Japan
[4] Kyushu Univ, Med Inst Bioregulat, Div Immunogenet, Dept Immunobiol & Neurosci, Fukuoka, Japan
[5] Kyushu Univ, Res Ctr Adv Immunol, Fukuoka, Japan
来源：
ALLERGY | 2018年 / 73卷 / 01期
关键词：
atopic dermatitis; interleukin-31; receptor; pruritus; T helper 2; IL-31; MONOCLONAL-ANTIBODY; CLIENT-OWNED DOGS; T-CELLS; ONCOSTATIN-M; LOKIVETMAB ZTS-00103289; SKIN INFLAMMATION; RELEASE IL-31; DOUBLE-BLIND; ITCH; PLACEBO;
D O I：
10.1111/all.13239
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (T(H)2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from T(H)2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.
引用
收藏
页码：29 / 36
页数：8
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