Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis

被引：184
|
作者：
Furue, M. [1 ,2 ,3 ]
Yamamura, K. [1 ,2 ]
Kido-Nakahara, M. [1 ,2 ]
Nakahara, T. [1 ,2 ]
Fukui, Y. [4 ,5 ]
机构：
[1] Kyushu Univ, Dept Dermatol, Grad Sch Med Sci, Fukuoka, Japan
[2] Kyushu Univ, Div Skin Surface Sensing, Grad Sch Med Sci, Fukuoka, Japan
[3] Kyushu Univ, Res & Clin Ctr Yusho & Dioxin, Kyushu Univ Hosp, Fukuoka, Japan
[4] Kyushu Univ, Med Inst Bioregulat, Div Immunogenet, Dept Immunobiol & Neurosci, Fukuoka, Japan
[5] Kyushu Univ, Res Ctr Adv Immunol, Fukuoka, Japan
来源：
ALLERGY | 2018年 / 73卷 / 01期
关键词：
atopic dermatitis; interleukin-31; receptor; pruritus; T helper 2; IL-31; MONOCLONAL-ANTIBODY; CLIENT-OWNED DOGS; T-CELLS; ONCOSTATIN-M; LOKIVETMAB ZTS-00103289; SKIN INFLAMMATION; RELEASE IL-31; DOUBLE-BLIND; ITCH; PLACEBO;
D O I：
10.1111/all.13239
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (T(H)2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from T(H)2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.
引用
收藏
页码：29 / 36
页数：8
相关论文
共 50 条
  • [31] Enhanced expression levels of interleukin-31 correlate with interleukin-4 and interleukin-13 in atopic and allergic contact dermatitis
    Neis, M. M.
    Peters, B.
    Dreuw, A.
    Bieber, T.
    Krieg, T.
    Stanzel, S.
    Heinrich, P. C.
    Merk, H. F.
    Baron, J. M.
    Hermanns, H. M.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 : 59 - 59
  • [32] Functional Regulation of Interleukin-31 Production by its Genetic Polymorphism in Patients with Extrinsic Atopic Dermatitis
    Hong, Chien-Hui
    Yu, Hsin-Su
    Ko, Ying-Chin
    Chang, Wei-Chiao
    Chuang, Hong-Yi
    Chen, Gwo-Shing
    Lee, Chih-Hung
    ACTA DERMATO-VENEREOLOGICA, 2012, 92 (04) : 430 - 432
  • [33] The ambiguous pruritogenic role of interleukin-31 in cutaneous T-cell lymphomas in comparison to atopic dermatitis: a review
    Olszewska, Berenika
    Sokolowska-Wojdylo, Malgorzata
    Lakomy, Joanna
    Nowicki, Roman J.
    POSTEPY DERMATOLOGII I ALERGOLOGII, 2020, 37 (03): : 319 - 325
  • [34] Interleukin-31 receptor and pruritus associated with primary localized cutaneous amyloidosis: reply from the authors
    Tey, H. L.
    Nattkemper, L. A.
    Cao, T.
    Pramono, Z. A. D.
    Yosipovitch, G.
    BRITISH JOURNAL OF DERMATOLOGY, 2016, 175 (02) : 433 - 434
  • [35] Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring
    Ezzat, M. H. M.
    Hasan, Z. E.
    Shaheen, K. Y. A.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2011, 25 (03) : 334 - 339
  • [36] Characteristics of Pruritus according to Morphological Phenotype of Psoriasis and Association with Neuropeptides and Interleukin-31
    Park, Sung-Min
    Kim, Gun-Wook
    Kim, Hoon-Soo
    Ko, Hyun-Chang
    Kim, Moon-Bum
    Kim, Byung-Soo
    ANNALS OF DERMATOLOGY, 2020, 32 (01) : 1 - 7
  • [37] Characteristics of pruritus according to morphological phenotype of psoriasis and association with neuropeptides and interleukin-31
    Park, Sung-Min
    Sim, Woo-Haing
    Kim, Jeong-Min
    Ko, Hyun-Chang
    Kim, Byung-Soo
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2017, 76 (06) : AB67 - AB67
  • [38] Interleukin-31: The "itchy" cytokine in inflammation and therapy
    Datsi, Angeliki
    Steinhoff, Martin
    Ahmad, Fareed
    Alam, Majid
    Buddenkotte, Joerg
    ALLERGY, 2021, 76 (10) : 2982 - 2997
  • [39] Analyzing the Antinociceptive Effect of Interleukin-31 in Mice
    Arai, Iwao
    Tsuji, Minoru
    Takahashi, Kohei
    Saito, Saburo
    Takeda, Hiroshi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (14)
  • [40] Interleukin-31 as early Success Marker of Immunotherapy?
    Bauer-Delto, Angelika
    ALLERGO JOURNAL, 2013, 22 (03) : 209 - 209
12345