The Highly Efficient 1,4-Addition of TMSCN to Aromatic Enones Catalyzed by CsF with Water as the Additive

被引：27
|
作者：
Yang, Jingya [1 ,2 ]
Wang, Yinxian [1 ]
Wu, Shaoxiang [1 ]
Chen, Fu-Xue [1 ]
机构：
[1] Beijing Inst Technol, Sch Chem Engn & Environm, Dept Appl Chem, Beijing 100081, Peoples R China
[2] NW Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Peoples R China
来源：
SYNLETT | 2009年 / 20期
关键词：
1,4-addition reaction; enones; nitriles; regioselectivity; CsF; ENANTIOSELECTIVE CONJUGATE ADDITION; CESIUM FLUORIDE; ALPHA; BETA-UNSATURATED IMIDES; MICHAEL ADDITION; TRIMETHYLSILYL CYANIDE; GRIGNARD-REAGENTS; RING; TRIFLUOROMETHYLATION; CYANATION; KETONES;
D O I：
10.1055/s-0029-1218376
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient 1,4-addition of TMSCN to aromatic enones has been achieved in excellent yields (91-99%) by CsF (1 mol%) as the catalyst and H2O (4 equiv) as the additive in refluxing dioxane within 2-7 hours.
引用
收藏
页码：3365 / 3367
页数：3
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