The Highly Efficient 1,4-Addition of TMSCN to Aromatic Enones Catalyzed by CsF with Water as the Additive

被引：27

作者：

Yang, Jingya ^{[1
,2
]}

Wang, Yinxian ^{[1
]}

Wu, Shaoxiang ^{[1
]}

Chen, Fu-Xue ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Chem Engn & Environm, Dept Appl Chem, Beijing 100081, Peoples R China

[2] NW Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Peoples R China

来源：

SYNLETT | 2009年 / 20期

关键词：

1,4-addition reaction; enones; nitriles; regioselectivity; CsF; ENANTIOSELECTIVE CONJUGATE ADDITION; CESIUM FLUORIDE; ALPHA; BETA-UNSATURATED IMIDES; MICHAEL ADDITION; TRIMETHYLSILYL CYANIDE; GRIGNARD-REAGENTS; RING; TRIFLUOROMETHYLATION; CYANATION; KETONES;

D O I：

10.1055/s-0029-1218376

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient 1,4-addition of TMSCN to aromatic enones has been achieved in excellent yields (91-99%) by CsF (1 mol%) as the catalyst and H2O (4 equiv) as the additive in refluxing dioxane within 2-7 hours.

引用

页码：3365 / 3367

页数：3

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