Coupling reactions with haloaromatic amines and alcohols for a practical synthetic route to 2-substituted aminophenyl and hydroxyphenyl pyridines

被引：9

作者：

Kim, Seung-Hoi ^{[1
]}

Rieke, Reuben D. ^{[1
]}

机构：

[1] Rieke Met Inc, Lincoln, NE 68521 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 50期

关键词：

DIRECT ARYLATION; CROSS-COUPLINGS; N-OXIDES; EFFICIENT; 2,2'-BIPYRIDINES; MAGNESIATION; CHLORIDE; YIELD;

D O I：

10.1016/j.tetlet.2009.09.160

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthetic route to 2-substituted aminophenyl and hydroxyphenyl pyridines has been developed. It has been accomplished by the cross-coupling reactions of readily available 2-pyridylzinc bromides with haloaromatic amines and alcohols under mild conditions. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6985 / 6988

页数：4

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