Esterification of Unprotected α-Amino Acids in Ionic Liquids as the Reaction Media

被引：10

作者：

Biondini, Daniele ^{[1
]}

Brinchi, Lucia ^{[1
]}

Germani, Raimondo ^{[1
]}

Goracci, Laura ^{[1
]}

Savelli, Gianfranco ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim, CEMIN, I-06123 Perugia, Italy

来源：

LETTERS IN ORGANIC CHEMISTRY | 2010年 / 7卷 / 01期

关键词：

Ionic liquid; esterification; amino acids; nucleophilic substitution;

D O I：

10.2174/157017810790533940

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ionic liquid 1,3-dimethylimidazolium methanesulfonate was used to prepare amino acids benzylic esters from unprotected amino acids and benzyl chloride. Esterification of several amino acids was achieved with satisfactory yields: by-products can be removed by a simple work-up procedure to afford the pure product. The described method is simple, mild, rapid and save.

引用

页码：39 / 44

页数：6

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