Esterification of Unprotected α-Amino Acids in Ionic Liquids as the Reaction Media

被引：10
|
作者：
Biondini, Daniele [1 ]
Brinchi, Lucia [1 ]
Germani, Raimondo [1 ]
Goracci, Laura [1 ]
Savelli, Gianfranco [1 ]
机构：
[1] Univ Perugia, Dipartimento Chim, CEMIN, I-06123 Perugia, Italy
来源：
LETTERS IN ORGANIC CHEMISTRY | 2010年 / 7卷 / 01期
关键词：
Ionic liquid; esterification; amino acids; nucleophilic substitution;
D O I：
10.2174/157017810790533940
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ionic liquid 1,3-dimethylimidazolium methanesulfonate was used to prepare amino acids benzylic esters from unprotected amino acids and benzyl chloride. Esterification of several amino acids was achieved with satisfactory yields: by-products can be removed by a simple work-up procedure to afford the pure product. The described method is simple, mild, rapid and save.
引用
收藏
页码：39 / 44
页数：6
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