Microwave-assisted "green" synthesis of 2-alkyl/arylbenzothiazoles in one pot: A facile approach to anti-tumor drugs

被引：53

作者：

Kamila, Sukanta ^{[1
]}

Koh, Benjamin ^{[1
]}

Biehl, Edward R. ^{[1
]}

机构：

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 06期

关键词：

D O I：

10.1002/jhet.5570430627

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new 2-alkyl/arylbenzothiazoles has been synthesized on the basis of the potent and selective in vitro anti-tumor properties of 2-(3,4-diethoxyphenyl)-5-fluorobenzothiazole. The synthesis of benzothiazole analogs was achieved via microwave irradiation of a 1:1 mixture of o-aminothiophenol and alkyl/aryl acylacetonitriles at temperature of 200 degrees C for 10 min. The yields are very good to excellent. All the products were characterized by H-1 nmr, C-13 nmr and elemental analysis.

引用

页码：1609 / 1612

页数：4

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