Total synthesis of cyclic heptapeptide Rolloamide B

被引：12
|
作者：
El Khatib, Mirna [1 ]
Elagawany, Mohamed [1 ,2 ,3 ]
Caliskan, Eray [1 ]
Davis, Emily Faith [1 ]
Faidallah, Hassan M. [4 ]
El-feky, Said A. [2 ]
Katritzky, Alan R. [1 ,4 ]
机构：
[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA
[2] Zagazig Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Zagazig 44519, Egypt
[3] Misr Univ Sci & Technol, Coll Pharm, Dept Organ Chem, Al Motamayez Dist, Egypt
[4] King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 26期
关键词：
POSTTRANSLATIONAL MODIFICATIONS; PEPTIDE-SYNTHESIS; PROTEIN-SYNTHESIS; MACROCYCLES; LIGATION; PROLINE; STRATEGIES; CHEMISTRY;
D O I：
10.1039/c3cc39291k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first total synthesis of Rolloamide B, a cyclic proline-enriched heptapeptide, is reported. This work features solution phase benzotriazole-mediated peptide synthesis ligating native amino acids.
引用
收藏
页码：2631 / 2633
页数：3
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