Total synthesis of cyclic heptapeptide Rolloamide B

被引：12

作者：

El Khatib, Mirna ^{[1
]}

Elagawany, Mohamed ^{[1
,2
,3
]}

Caliskan, Eray ^{[1
]}

Davis, Emily Faith ^{[1
]}

Faidallah, Hassan M. ^{[4
]}

El-feky, Said A. ^{[2
]}

Katritzky, Alan R. ^{[1
,4
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Zagazig Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Zagazig 44519, Egypt

[3] Misr Univ Sci & Technol, Coll Pharm, Dept Organ Chem, Al Motamayez Dist, Egypt

[4] King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 26期

关键词：

POSTTRANSLATIONAL MODIFICATIONS; PEPTIDE-SYNTHESIS; PROTEIN-SYNTHESIS; MACROCYCLES; LIGATION; PROLINE; STRATEGIES; CHEMISTRY;

D O I：

10.1039/c3cc39291k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first total synthesis of Rolloamide B, a cyclic proline-enriched heptapeptide, is reported. This work features solution phase benzotriazole-mediated peptide synthesis ligating native amino acids.

引用

页码：2631 / 2633

页数：3

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