Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK-1092 in Healthy Subjects (HS)

被引：1
|
作者：
Morrow, Linda
Grimm, Michael
Beysen, Carine
Walford, Geoffrey
Duncan, Kelly
Mitra, Pranab K.
Vaddady, Pavan
Hompesch, Marcus
机构：
来源：
DIABETES | 2020年 / 69卷
关键词：
D O I：
10.2337/db20-107-LB
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
107-LB
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Ascending single-dose study of safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy subjects
    Abbas, Richat
    Hug, Bruce A.
    Leister, Cathie
    Burns, Jaime
    Sonnichsen, Daryl
    [J]. MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [22] Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Sotagliflozin After Multiple Ascending Doses in Chinese Healthy Subjects
    He, Xuemei
    Gao, Xin
    Xie, Panpan
    Liu, Yuan
    Bai, Wenjing
    Liu, Yue
    Shi, Aixin
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2022, 16 : 2967 - 2980
  • [23] Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of TAK-935 in Healthy Subjects
    Wang, Shining
    Chen, Grace
    Uz, Tolga
    Affinito, John
    [J]. NEUROLOGY, 2018, 90
  • [24] Single Ascending Dose Study to Assess Pharmacokinetic Linearity, Safety, and Tolerability of Trimetazidine - Modified Release in Healthy Human Subjects
    Koernicke, Thomas
    Arora, Deepa
    Samad, Abdus
    Kaplan, Sigal
    Domahidy, Monika
    de Voogd, Hanka
    Boehmert, Stella
    Ramos, Rita Silveira
    Jain, Shashank
    [J]. DRUG RESEARCH, 2020, 70 (10) : 472 - 477
  • [25] A Randomized, Placebo-Controlled, Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects
    Hanrahan, John P.
    Wakefield, James D.
    Wilson, Phebe J.
    Mihova, Marina
    Chickering, Jennifer G.
    Ruff, Dennis
    Hall, Michael
    Milne, G. Todd
    Currie, Mark G.
    Profy, Albert T.
    [J]. CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2019, 8 (05): : 564 - 575
  • [26] Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Single Doses of Bivalirudin in Healthy Chinese Subjects
    Zhang, Dongmei
    Wang, Zining
    Zhao, Xia
    Lu, Wei
    Gu, Jingkai
    Cui, Yimin
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2011, 34 (12) : 1841 - 1848
  • [27] Ascending Single-Dose Study of the Safety Profile, Tolerability, and Pharmacokinetics of Bosutinib Coadministered With Ketoconazole to Healthy Adult Subjects
    Abbas, Richat
    Leister, Cathie
    El Gaaloul, Myriam
    Chalon, Stephan
    Sonnichsen, Daryl
    [J]. CLINICAL THERAPEUTICS, 2012, 34 (09) : 2011 - 2019
  • [28] Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects
    Sheng, Lei
    Cao, Wei
    Lin, Pingping
    Chen, Weili
    Xu, Hongrong
    Zhong, Chunjiu
    Yuan, Fei
    Chen, Hanjing
    Li, Hui
    Liu, Chao
    Yang, Mengjie
    Li, Xuening
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 15 : 1101 - 1110
  • [29] Keverprazan, a novel potassium-competitive acid blocker: Single ascending dose safety, tolerability, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
    Zhou, Sufeng
    Xie, Lijun
    Zhou, Chen
    Zhao, Yuqing
    Wang, Lu
    Ding, Sijia
    Chen, Juan
    Zhu, Bei
    Su, Mei
    Shao, Feng
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 190
  • [30] Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alirocumab in Healthy Chinese Subjects: A Randomized, Double-Blind, Placebo-Controlled, Ascending Single-Dose Study
    Haiyan Li
    Yudong Wei
    Zhenhua Yang
    Shuang Zhang
    Xiuxiu Xu
    Mengmeng Shuai
    Olivier Vitse
    Yiwen Wu
    Marie T. Baccara-Dinet
    Yi Zhang
    Jianyong Li
    [J]. American Journal of Cardiovascular Drugs, 2020, 20 : 489 - 503
12345