Pictet-Spengler synthesis of pyrazole-fused β-carbolines

被引：11

作者：

Fasfous, II

El-Abadelah, MM ^{[1
]}

Sabri, SS

机构：

[1] Univ Jordan, Fac Sci, Chem Dept, Amman, Jordan

[2] Univ Sharjah, Fac Arts & Sci, Sharajah, U Arab Emirates

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2002年 / 39卷 / 01期

关键词：

D O I：

10.1002/jhet.5570390133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of new pyrazolo[4,3-c]beta-carbolines (8a,b) is achieved by condensation of the appropriate aldehyde with 3-(4-amino-1,3-dimethylpyrazol-5-yl)indole (4) under Pictet- Spengler reaction conditions. Regioselective cyclization occurred at the usual indole C-2 position as evidenced from the H-1- and C-13 nmr spectra of 8a,b which lack the pyrrolic H-2 signal, present in 4 (delta 7.26, 1H, d, J(CH-NH) = 2.5 Hz).

引用

页码：225 / 227

页数：3

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