Target Ablation of PTH/PTHrP Receptor (PPR) in Osteocytes Induces Hypocalcemia and Impairs Bone Structure

被引:0
|
作者
Divieti, P. P. [1 ]
Powell, W. F. [1 ]
Kobayashi, T. [1 ]
Harris, S. [2 ]
Bringhurst, F. [1 ]
机构
[1] Harvard Univ, Sch Med, Mass Gen Hosp, Endocrine Unit, Boston, MA USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Periodont, San Antonio, TX 78229 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S45 / S45
页数:1
相关论文
共 50 条
  • [31] Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the Type I PTH/PTHrP receptor
    Verheijen, MHG
    Karperien, M
    Chung, UI
    van Wijuen, M
    Heystek, H
    Hendriks, JAA
    Veltmaat, JM
    Lanske, B
    Li, E
    Löwik, CWGM
    de Laat, SW
    Kronenberg, HM
    Defize, LHK
    MECHANISMS OF DEVELOPMENT, 1999, 81 (1-2) : 151 - 161
  • [32] A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism
    Lee, Sihoon
    Mannstadt, Michael
    Guo, Jun
    Kim, Seul Min
    Yi, Hyon-Seung
    Khatri, Ashok
    Dean, Thomas
    Okazaki, Makoto
    Gardella, Thomas J.
    Jueppner, Harald
    JOURNAL OF BONE AND MINERAL RESEARCH, 2015, 30 (10) : 1803 - 1813
  • [33] In vivo expression of a constitutively active PTH/PTHrP receptor (PPR) in odontoblasts (ODs) alters OD and ameloblast (AB) function and maturation.
    Calvi, LM
    Shin, HI
    Knight, MC
    Saxton, JM
    Kronenberg, HM
    Schipani, E
    JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 : S547 - S547
  • [34] Modulation of bone remodeling by osteoprotegerin in mice expressing a constitutively active PTH/PTHrP receptor.
    Chiusaroli, R
    Knight, MC
    Kostenuik, P
    Schipani, E
    JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 : S42 - S42
  • [35] Targeted disruption of androgen receptor in mouse osteocytes: The androgen receptor in osteocytes is important for the maintenance of bone structure in males
    Sinnesael, M.
    Claessens, F.
    Boonen, S.
    Vanderschueren, D.
    BONE, 2012, 50 : S60 - S60
  • [36] HUMAN PODOCYTES EXPRESS A PTH/PTHRP RECEPTOR (PTH-R) DISTINCT FROM THE ONE CLONED FROM BONE AND HUMAN KIDNEY
    URENA, P
    ARDAILLOU, N
    JUPPNER, H
    GUERIS, J
    SEGRE, G
    RONCO, P
    ARDAILLOU, R
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1994, 5 (03): : 891 - 891
  • [37] INSITU LOCALIZATION OF PTH/PTHRP RECEPTOR MESSENGER-RNA IN THE BONE OF FETAL AND YOUNG-RATS
    LEE, K
    DEEDS, JD
    BOND, AT
    JUPPNER, H
    ABOUSAMRA, AB
    SEGRE, GV
    BONE, 1993, 14 (03) : 341 - 345
  • [38] Constitutively active PTH/PTHrP (PTHR) receptor signaling by breast cancer cells decreases bone metastases and TGFβ-stimulated PTHrP production.
    Rankin, W
    Grubbs, BG
    Chirgwin, JM
    Dallas, M
    Jueppner, H
    Schipani, E
    Mundy, GR
    Guise, TA
    JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 : S292 - S292
  • [39] Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: The marrow ablation model under PTH challenge
    Wade-Gueye, Ndeye Marieme
    Boudiffa, Maya
    Vanden-Bossche, Arnaud
    Laroche, Norbert
    Aubin, Jane E.
    Vico, Laurence
    Lafage-Proust, Marie-Helene
    Malaval, Luc
    BONE, 2012, 50 (05) : 1064 - 1073
  • [40] Human PTH-(7-84) inhibits bone resorption in vitro via actions independent of the type 1 PTH/PTHrP receptor
    Divieti, P
    John, MR
    Jüppner, H
    Bringhurst, FR
    ENDOCRINOLOGY, 2002, 143 (01) : 171 - 176