Facile synthesis of 1,1-disubstituted taurines

被引：43
|
作者：
Huang, JX [1 ]
Du, DM [1 ]
Xu, JX [1 ]
机构：
[1] Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2006年 / 02期
关键词：
amino acid; aminoalkanesulfonic acid; epoxide; episulfide; ketone; synthesis; taurine;
D O I：
10.1055/s-2005-924767
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 1,1-disubstituted taurines was synthesized expeditiously from ketones via the Corey-Chaykovsky epoxidation with dimethylsulfonium methylide, episulfidation with potassium sulfocyanate, ring-opening reaction with ammonia in the presence of,silver nitrate, followed by treatment with hydrogen Sulfide and oxidation with performic acid.
引用
收藏
页码：315 / 319
页数：5
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