Anti-Inflammatory Effects of Usnic Acid in Breast Cancer

被引：4

作者：

Yildirim, M. ^{[1
]}

Degirmenci, U. ^{[2
]}

Akkapulu, M. ^{[1
]}

Gungor, M. ^{[3
]}

Oztornaci, R. O. ^{[4
]}

Berkoz, M. ^{[5
]}

Comelekoglu, U. ^{[6
]}

Yalin, A. E. ^{[1
]}

Yalin, S. ^{[1
]}

机构：

[1] Mersin Univ, Fac Pharm, Dept Biochem, Mersin, Turkey

[2] Harran Univ, Fac Pharm, Dept Biochem, Sanliurfa, Turkey

[3] Sanko Univ, Fac Med, Dept Biochem, Gaziantep, Turkey

[4] Mersin Univ, Fac Med, Dept Biostat, Mersin, Turkey

[5] Van Yuzunci Yil Univ, Fac Pharm, Dept Biochem, Van, Turkey

[6] Mersin Univ, Fac Med, Dept Biophys, Mersin, Turkey

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2022年 / 48卷 / SUPPL 1期

关键词：

usnic acid; breast cancer; anti-inflammatory; MCF-7; oxidative stress;

D O I：

10.1134/S1068162023010296

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cancer is the most common type of cancer among women. Usnic acid has anticancer and anti-inflammatory potential. In this study, we evaluated the effects of usnic acid on inflammation and oxidative stress in the breast cancer cell line (MCF-7). Cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) gene expression, cytokines, nitric oxide (NO), prostaglandin E2 (PGE2) levels and oxidative stress were measured in all groups. Our study showed that usnic acid was decreased NO, VEGF, PGE2 levels, gene expression levels of COX-2 and iNOS in the meantime cytokines (IL 2, CXCL 10, CXCL8, CCL2 (MCP-1), TNF-alpha, IL-6), glutathione levels, moreover decreased GSH and increased MDA levels in dose depended manner. According to our evidence usnic acid was showed potential cytotoxic, anti-inflammatory and pro oxidant role.

引用

页码：S110 / S114

页数：5

共 50 条

[31] Association of aspirin and nonsteroidal anti-inflammatory drug use with breast cancer
Johnson, TW
Anderson, KE
Lazovich, D
Folsom, AR
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2002, 11 (12) : 1586 - 1591
[32] Synthesis and anti-inflammatory activity of novel triazole hybrids of (+)-usnic acid, the major dibenzofuran metabolite of the lichen Usnea longissima
Vanga, Nagi Reddy
Kota, Anudeep
Sistla, Ramakrishna
Uppuluri, Mallavadhani
MOLECULAR DIVERSITY, 2017, 21 (02) : 273 - 282
[33] Synthesis and anti-inflammatory activity of novel triazole hybrids of (+)-usnic acid, the major dibenzofuran metabolite of the lichen Usnea longissima
Nagi Reddy Vanga
Anudeep Kota
Ramakrishna Sistla
Mallavadhani Uppuluri
Molecular Diversity, 2017, 21 : 273 - 282
[34] Anti-inflammatory effects of α-tocopherol
Singh, U
Jialal, I
VITAMIN E AND HEALTH, 2004, 1031 : 195 - 203
[35] Anti-inflammatory effects of tetracyclines
Schaller, M.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017, 31 (11) : 1774 - 1774
[36] ANTI-INFLAMMATORY EFFECTS OF APAMIN
OVCHAROV, R
SHKENDEROV, S
MIHAILOVA, S
TOXICON, 1976, 14 (06) : 441 - 447
[37] The relationship of nonsteroidal anti-inflammatory drug use to the risk of breast cancer
Coogan, PF
Rao, RS
Rosenberg, L
Palmer, JR
Strom, BL
Zauber, AG
Stolley, PD
Shapiro, S
PREVENTIVE MEDICINE, 1999, 29 (02) : 72 - 76
[38] Anti-inflammatory effects of insulin
Dandona, Paresh
Chaudhuri, Ajay
Mohanty, Priya
Ghanim, Husam
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2007, 10 (04): : 511 - 517
[39] ANTI-INFLAMMATORY EFFECTS OF COUNTERIRRITANTS
LADEN, C
BLACKWELL, RQ
FOSDICK, LS
AMERICAN JOURNAL OF PHYSIOLOGY, 1958, 195 (03): : 712 - 718
[40] Anti-inflammatory effects of alcohol
Mascitelli, L
Pezzetta, F
ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (19) : 2393 - 2393

← 1 2 3 4 5 →