Anti-Inflammatory Effects of Usnic Acid in Breast Cancer

被引：4
|
作者：
Yildirim, M. [1 ]
Degirmenci, U. [2 ]
Akkapulu, M. [1 ]
Gungor, M. [3 ]
Oztornaci, R. O. [4 ]
Berkoz, M. [5 ]
Comelekoglu, U. [6 ]
Yalin, A. E. [1 ]
Yalin, S. [1 ]
机构：
[1] Mersin Univ, Fac Pharm, Dept Biochem, Mersin, Turkey
[2] Harran Univ, Fac Pharm, Dept Biochem, Sanliurfa, Turkey
[3] Sanko Univ, Fac Med, Dept Biochem, Gaziantep, Turkey
[4] Mersin Univ, Fac Med, Dept Biostat, Mersin, Turkey
[5] Van Yuzunci Yil Univ, Fac Pharm, Dept Biochem, Van, Turkey
[6] Mersin Univ, Fac Med, Dept Biophys, Mersin, Turkey
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2022年 / 48卷 / SUPPL 1期
关键词：
usnic acid; breast cancer; anti-inflammatory; MCF-7; oxidative stress;
D O I：
10.1134/S1068162023010296
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
cancer is the most common type of cancer among women. Usnic acid has anticancer and anti-inflammatory potential. In this study, we evaluated the effects of usnic acid on inflammation and oxidative stress in the breast cancer cell line (MCF-7). Cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) gene expression, cytokines, nitric oxide (NO), prostaglandin E2 (PGE2) levels and oxidative stress were measured in all groups. Our study showed that usnic acid was decreased NO, VEGF, PGE2 levels, gene expression levels of COX-2 and iNOS in the meantime cytokines (IL 2, CXCL 10, CXCL8, CCL2 (MCP-1), TNF-alpha, IL-6), glutathione levels, moreover decreased GSH and increased MDA levels in dose depended manner. According to our evidence usnic acid was showed potential cytotoxic, anti-inflammatory and pro oxidant role.
引用
收藏
页码：S110 / S114
页数：5
相关论文
共 50 条
  • [11] Anti-inflammatory effects of hydroxycinnamic acid derivatives
    Nagasaka, Reiko
    Chotimarkorn, Chatchawan
    Shafiqul, Islam Md.
    Hori, Masatoshi
    Ozaki, Hiroshi
    Ushio, Hideki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 358 (02) : 615 - 619
  • [12] The anti-inflammatory effects of quinolinic acid in the rat
    Heyliger, SO
    Mazzio, EA
    Soliman, KFA
    LIFE SCIENCES, 1999, 64 (14) : 1177 - 1187
  • [13] A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases
    Luo, Chunxu
    Zou, Lin
    Sun, Huijun
    Peng, Jinyong
    Gao, Cong
    Bao, Liuchi
    Ji, Renpeng
    Jin, Yue
    Sun, Shuangyong
    FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [14] Potential of Anti-inflammatory Molecules in the Chemoprevention of Breast Cancer
    Gadi, Vaishnavi
    Shetty, Saritha Rakesh
    RECENT ADVANCES IN INFLAMMATION & ALLERGY DRUG DISCOVERY, 2022, 16 (02): : 60 - 76
  • [15] Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects
    Kuriki, Kiyonori
    Wakai, Kenji
    Matsuo, Keitaro
    Hiraki, Akio
    Suzuki, Takeshi
    Yamamura, Yoshitaka
    Yamao, Kenji
    Nakamura, Tsuneya
    Tatematsu, Masae
    Tajima, Kazuo
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (11) : 2406 - 2415
  • [16] Anti-inflammatory effects of docosahexaenoic acid: Implications for its cancer chemopreventive potential
    Yum, Hye-Won
    Na, Hye-Kyung
    Surh, Young-Joon
    SEMINARS IN CANCER BIOLOGY, 2016, 40-41 : 141 - 159
  • [17] Poly-ε-Caprolactone Microsphere Polymers Containing Usnic Acid: Acute Toxicity and Anti-Inflammatory Activity
    Barbosa, Jessica A. P.
    Franco, Eryvelton S.
    Silva, Camilla V. N. S.
    Bezerra, Tatiane O.
    Santana, Marllon A. N.
    Junior, Carlson H. R. C.
    Silva, Teresinha G.
    Santos, Noemia P. S.
    Maia, Maria B. S.
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 2017
  • [18] A Comparative Survey of Anti-Melanoma and Anti-Inflammatory Potential of Usnic Acid Enantiomers-A Comprehensive In Vitro Approach
    Galanty, Agnieszka
    Zagrodzki, Pawel
    Gdula-Argasinska, Joanna
    Grabowska, Karolina
    Koczurkiewicz-Adamczyk, Paulina
    Wrobel-Biedrawa, Dagmara
    Podolak, Irma
    Pekala, Elzbieta
    Pasko, Pawel
    PHARMACEUTICALS, 2021, 14 (09)
  • [19] Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2
    Graff, Emily C.
    Fang, Han
    Wanders, Desiree
    Judd, Robert L.
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2016, 65 (02): : 102 - 113
  • [20] The anti-inflammatory effects of Pseudorlaric acid D on atherosclerosis
    Chen, Jiayi
    Du, Rongxue
    Wang, Wei
    An, Fang
    Ye, Lu
    Chen, Hong
    Jiang, Tao
    Li, Tan
    Zhao, Jihong
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 125
12345