Anti-Inflammatory Effects of Usnic Acid in Breast Cancer

被引：4

作者：

Yildirim, M. ^{[1
]}

Degirmenci, U. ^{[2
]}

Akkapulu, M. ^{[1
]}

Gungor, M. ^{[3
]}

Oztornaci, R. O. ^{[4
]}

Berkoz, M. ^{[5
]}

Comelekoglu, U. ^{[6
]}

Yalin, A. E. ^{[1
]}

Yalin, S. ^{[1
]}

机构：

[1] Mersin Univ, Fac Pharm, Dept Biochem, Mersin, Turkey

[2] Harran Univ, Fac Pharm, Dept Biochem, Sanliurfa, Turkey

[3] Sanko Univ, Fac Med, Dept Biochem, Gaziantep, Turkey

[4] Mersin Univ, Fac Med, Dept Biostat, Mersin, Turkey

[5] Van Yuzunci Yil Univ, Fac Pharm, Dept Biochem, Van, Turkey

[6] Mersin Univ, Fac Med, Dept Biophys, Mersin, Turkey

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2022年 / 48卷 / SUPPL 1期

关键词：

usnic acid; breast cancer; anti-inflammatory; MCF-7; oxidative stress;

D O I：

10.1134/S1068162023010296

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cancer is the most common type of cancer among women. Usnic acid has anticancer and anti-inflammatory potential. In this study, we evaluated the effects of usnic acid on inflammation and oxidative stress in the breast cancer cell line (MCF-7). Cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) gene expression, cytokines, nitric oxide (NO), prostaglandin E2 (PGE2) levels and oxidative stress were measured in all groups. Our study showed that usnic acid was decreased NO, VEGF, PGE2 levels, gene expression levels of COX-2 and iNOS in the meantime cytokines (IL 2, CXCL 10, CXCL8, CCL2 (MCP-1), TNF-alpha, IL-6), glutathione levels, moreover decreased GSH and increased MDA levels in dose depended manner. According to our evidence usnic acid was showed potential cytotoxic, anti-inflammatory and pro oxidant role.

引用

页码：S110 / S114

页数：5

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