Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer

被引：18

作者：

Stuart, Darrin D. ^{[1
]}

Sellers, William R. ^{[2
]}

机构：

[1] Novartis Inst Biomed Res, Emeryville, CA USA

[2] Novartis Inst Biomed Res, Cambridge, MA USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 05期

关键词：

BRAF; INHIBITION; MELANOMA; MUTATIONS; PHASE-2; IQGAP1;

D O I：

10.1038/nm.3195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The RAS-RAF-MEK-ERK signaling kinase pathway has been the focus of intense cancer drug development efforts because of its central role in tumor cell proliferation and survival. Although inhibitors of RAF and MEK provide therapeutic validation, tumor resistance challenges their effectiveness. Targeting scaffolding proteins such as IQGAP1 may be a new approach (pages 626–630).

引用

页码：538 / 540

页数：3

共 50 条

[41] Inhibition of Raf-MEK-ERK and Hypoxia pathways by Phyllanthus prevents metastasis in human lung (A549) cancer cell line
Lee, Sau Har
Jaganath, Indu Bala
Manikam, Rishya
Sekaran, Shamala Devi
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 13
[42] Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart
Umbarkar, Prachi
Tousif, Sultan
Singh, Anand P.
Anderson, Joshua C.
Zhang, Qinkun
Tallquist, Michelle D.
Woodgett, James
Lal, Hind
CIRCULATION RESEARCH, 2022, 131 (07) : 620 - 636
[43] Recent Developments in Anti-Cancer Agents Targeting the Ras/Raf/MEK/ERK Pathway
Wong, Kwong-Kwok
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2009, 4 (01) : 28 - 35
[44] Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors
McCubrey, James A.
Milella, Michele
Tafuri, Agostino
Martelli, Alberto M.
Lunghi, Paolo
Bonati, Antonio
Cervello, Melchiorre
Lee, John T.
Steelman, Linda S.
CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2008, 9 (06) : 614 - 630
[45] 复心合剂对心衰大鼠信号通路Raf-MEK-ERK的影响
薛一涛
李秋实
焦华琛
苏文革
中华中医药学刊, 2015, 33 (04) : 791 - 794
[46] Transient activation of the Raf-MEK-ERK: Pathway mimics HGF-induced tubulogenesis in MDCK cysts
Kats, ES
O'Brien, LE
Hansen, SH
Mostov, KE
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 478A - 479A
[47] Constant Activation of the RAF-MEK-ERK Pathway As a Diagnostic and Therapeutic Target in Hairy Cell Leukemia.
Tiacci, Enrico
Schiavoni, Gianluca
Martelli, Maria Paola
Boveri, Emanuela
Pacini, Roberta
Tabarrini, Alessia
Zibellini, Silvia
Santi, Alessia
Pettirossi, Valentina
Fortini, Elisabetta
Ascani, Stefano
Arcaini, Luca
Inghirami, Giorgio
Paulli, Marco
Falini, Brunangelo
BLOOD, 2012, 120 (21)
[48] The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression
Huilin Jin
Xiaoling Huang
Qihao Pan
Ning Ma
Xiaoshan Xie
Yue Wei
Fenghai Yu
Weijie Wen
Boyu Zhang
Peng Zhang
Xijie Chen
Jie Wang
Ran-yi Liu
Junzhong Lin
Xiangqi Meng
Mong-Hong Lee
Nature Communications, 15
[49] A novel Raf kinase inhibitor blocks the Raf/MEK/ERK pathway in tumor cells.
Wilhelm, S
Kennure, N
Housley, T
Katz, M
Wood, J
Lyons, J
Taylor, R
Knepper, M
Roscoe, W
Bollag, G
CLINICAL CANCER RESEARCH, 2000, 6 : 4547S - 4547S
[50] The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression
Jin, Huilin
Huang, Xiaoling
Pan, Qihao
Ma, Ning
Xie, Xiaoshan
Wei, Yue
Yu, Fenghai
Wen, Weijie
Zhang, Boyu
Zhang, Peng
Chen, Xijie
Wang, Jie
Liu, Ran-yi
Lin, Junzhong
Meng, Xiangqi
Lee, Mong-Hong
NATURE COMMUNICATIONS, 2024, 15 (01)

← 1 2 3 4 5 →