Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer

被引：18

作者：

Stuart, Darrin D. ^{[1
]}

Sellers, William R. ^{[2
]}

机构：

[1] Novartis Inst Biomed Res, Emeryville, CA USA

[2] Novartis Inst Biomed Res, Cambridge, MA USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 05期

关键词：

BRAF; INHIBITION; MELANOMA; MUTATIONS; PHASE-2; IQGAP1;

D O I：

10.1038/nm.3195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The RAS-RAF-MEK-ERK signaling kinase pathway has been the focus of intense cancer drug development efforts because of its central role in tumor cell proliferation and survival. Although inhibitors of RAF and MEK provide therapeutic validation, tumor resistance challenges their effectiveness. Targeting scaffolding proteins such as IQGAP1 may be a new approach (pages 626–630).

引用

页码：538 / 540

页数：3

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