NKG2D in NK and T cell-mediated immunity

被引：93
|
作者：
Ogasawara, K
Lanier, LL
机构：
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94143 USA
[3] Int Med Ctr Japan, Dept Intractable Dis, Div Clin Immunol, Res Inst,Shinjuku Ku, Tokyo, Japan
来源：
JOURNAL OF CLINICAL IMMUNOLOGY | 2005年 / 25卷 / 06期
基金：
美国国家卫生研究院;
关键词：
NK cells; NKG2D; DAP10; RAE-1; MICA; autoimmunity; bone marrow transplantation; T cell;
D O I：
10.1007/s10875-005-8786-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on gamma delta-TcR+ T cells and alpha beta-TcR+ CD8(+) T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.
引用
收藏
页码：534 / 540
页数：7
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