NKG2D in NK and T cell-mediated immunity

被引：93

作者：

Ogasawara, K

Lanier, LL

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94143 USA

[3] Int Med Ctr Japan, Dept Intractable Dis, Div Clin Immunol, Res Inst,Shinjuku Ku, Tokyo, Japan

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2005年 / 25卷 / 06期

基金：

美国国家卫生研究院;

关键词：

NK cells; NKG2D; DAP10; RAE-1; MICA; autoimmunity; bone marrow transplantation; T cell;

D O I：

10.1007/s10875-005-8786-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on gamma delta-TcR+ T cells and alpha beta-TcR+ CD8(+) T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.

引用

页码：534 / 540

页数：7

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