NKG2D in NK and T cell-mediated immunity

被引：93
|
作者：
Ogasawara, K
Lanier, LL
机构：
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94143 USA
[3] Int Med Ctr Japan, Dept Intractable Dis, Div Clin Immunol, Res Inst,Shinjuku Ku, Tokyo, Japan
来源：
JOURNAL OF CLINICAL IMMUNOLOGY | 2005年 / 25卷 / 06期
基金：
美国国家卫生研究院;
关键词：
NK cells; NKG2D; DAP10; RAE-1; MICA; autoimmunity; bone marrow transplantation; T cell;
D O I：
10.1007/s10875-005-8786-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on gamma delta-TcR+ T cells and alpha beta-TcR+ CD8(+) T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.
引用
收藏
页码：534 / 540
页数：7
相关论文
共 50 条
  • [1] NKG2D in NK and T Cell-Mediated Immunity
    Kouetsu Ogasawara
    Lewis L. Lanier
    Journal of Clinical Immunology, 2005, 25 : 534 - 540
  • [2] A role for NKG2D in NK cell-mediated resistance to poxvirus disease
    Fang, Min
    Lanier, Lewis L.
    Sigal, Luis J.
    PLOS PATHOGENS, 2008, 4 (02)
  • [3] "Acquired" NKG2D Ligand Stimulates NK Cell-mediated Tumor Immunosurveillance
    Wang, Dongfang
    Gu, Xiuling
    Liu, Xinjun
    Liu, Xiaoman
    Wang, Bin
    Lao, Fengxue
    Fang, Min
    JOURNAL OF IMMUNOTHERAPY, 2019, 42 (06) : 189 - 196
  • [4] Shed NKG2D ligand boosts NK cell immunity
    Narni-Mancinelli, Emilie
    Vivier, Eric
    CELL RESEARCH, 2015, 25 (06) : 651 - 652
  • [5] Shed NKG2D ligand boosts NK cell immunity
    Emilie Narni-Mancinelli
    Eric Vivier
    Cell Research, 2015, 25 : 651 - 652
  • [6] Differential Effects of Histone Deacetylases on the Expression of NKG2D Ligands and NK Cell-Mediated Anticancer Immunity in Lung Cancer Cells
    Cho, Haeryung
    Son, Woo-Chang
    Lee, Young-Shin
    Youn, Eun Jung
    Kang, Chi-Dug
    Park, You-Soo
    Bae, Jaeho
    MOLECULES, 2021, 26 (13):
  • [7] Potential of the NKG2D/NKG2DL Axis in NK Cell-Mediated Clearance of the HIV-1 Reservoir
    Desimio, Maria G.
    Covino, Daniela A.
    Doria, Margherita
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (18)
  • [8] Upregulation of Myc promotes the evasion of NK cell-mediated immunity through suppression of NKG2D ligands in K562 cells
    Lee, Young-Shin
    Heo, Woong
    Son, Cheol-Hun
    Kang, Chi-Dug
    Park, You-Soo
    Bae, Jaeho
    MOLECULAR MEDICINE REPORTS, 2019, 20 (04) : 3301 - 3307
  • [9] Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma
    Belting, Lena
    Hoemberg, Nadine
    Przewoznik, Margarethe
    Brenner, Christoph
    Riedel, Tanja
    Flatley, Andrew
    Polic, Bojan
    Busch, Dirk H.
    Roecken, Martin
    Mocikat, Ralph
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (09) : 2593 - 2601
  • [10] Fas ligand–mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity
    Veronika Groh
    Kimberly Smythe
    Zhenpeng Dai
    Thomas Spies
    Nature Immunology, 2006, 7 : 755 - 762
12345