New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships

被引：4

作者：

Zhou, Bin ^{[1
,2
,3
,4
]}

Shetye, Gauri ^{[3
]}

Wolf, Nina M. ^{[3
]}

Chen, Shao-Nong ^{[1
,2
,3
]}

Qader, Mallique ^{[3
]}

Ray, G. Joseph ^{[1
,2
,3
]}

Lankin, David C. ^{[1
,2
,3
]}

Cho, Sanghyun ^{[3
]}

Cheng, Jinhua ^{[5
]}

Suh, Joo-Won ^{[5
]}

Franzblau, Scott G. ^{[1
,2
,3
]}

McAlpine, James B. ^{[1
,2
,3
]}

Pauli, Guido F. ^{[1
,2
,3
]}

机构：

[1] Univ Illinois, Pharmacognosy Inst, Coll Pharm, Chicago, IL 60612 USA

[2] Univ Illinois, Dept Pharmaceut Sci Coll Pharm, Chicago, IL 60612 USA

[3] Univ Illinois, Inst TB Res, Coll Pharm, Chicago, IL 60612 USA

[4] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[5] Myongji Univ, Myongji Bioefficacy Res Ctr, Yongin 17058, Gyeonggi Do, South Korea

来源：

ORGANIC LETTERS | 2022年

基金：

美国国家卫生研究院;

关键词：

ABSOLUTE-CONFIGURATION;

D O I：

10.1021/acs.orglett.2c02493

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new rufomycins, compounds 1-4, named rufomycins 56, 57, 58, and 61, respectively, exhibiting new skeletal features, were obtained from Streptomyces atratus strain MJM3502 and were fully characterized. Compounds 1 and 2 possess a 4imidazolidinone ring not previously encountered in this family of cyclopeptides, thereby resulting in a [5,17] bicyclic framework. The in vitro anti -Mycobacterium tuberculosis potency of compounds 3 and 4 is remarkable, with minimum inhibitory concentration values of 8.5 and 130 nM, respectively.

引用

页码：7265 / 7270

页数：6

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