New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships

被引：4
|
作者：
Zhou, Bin [1 ,2 ,3 ,4 ]
Shetye, Gauri [3 ]
Wolf, Nina M. [3 ]
Chen, Shao-Nong [1 ,2 ,3 ]
Qader, Mallique [3 ]
Ray, G. Joseph [1 ,2 ,3 ]
Lankin, David C. [1 ,2 ,3 ]
Cho, Sanghyun [3 ]
Cheng, Jinhua [5 ]
Suh, Joo-Won [5 ]
Franzblau, Scott G. [1 ,2 ,3 ]
McAlpine, James B. [1 ,2 ,3 ]
Pauli, Guido F. [1 ,2 ,3 ]
机构：
[1] Univ Illinois, Pharmacognosy Inst, Coll Pharm, Chicago, IL 60612 USA
[2] Univ Illinois, Dept Pharmaceut Sci Coll Pharm, Chicago, IL 60612 USA
[3] Univ Illinois, Inst TB Res, Coll Pharm, Chicago, IL 60612 USA
[4] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[5] Myongji Univ, Myongji Bioefficacy Res Ctr, Yongin 17058, Gyeonggi Do, South Korea
来源：
ORGANIC LETTERS | 2022年
基金：
美国国家卫生研究院;
关键词：
ABSOLUTE-CONFIGURATION;
D O I：
10.1021/acs.orglett.2c02493
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new rufomycins, compounds 1-4, named rufomycins 56, 57, 58, and 61, respectively, exhibiting new skeletal features, were obtained from Streptomyces atratus strain MJM3502 and were fully characterized. Compounds 1 and 2 possess a 4imidazolidinone ring not previously encountered in this family of cyclopeptides, thereby resulting in a [5,17] bicyclic framework. The in vitro anti -Mycobacterium tuberculosis potency of compounds 3 and 4 is remarkable, with minimum inhibitory concentration values of 8.5 and 130 nM, respectively.
引用
收藏
页码：7265 / 7270
页数：6
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