Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine

被引：22
|
作者：
Liu, Jing [1 ]
Fitzgerald, Anne E. [1 ]
Mani, Neelakandha S. [1 ]
机构：
[1] Janssen Res & Dev LLC, San Diego, CA 92121 USA
来源：
SYNTHESIS-STUTTGART | 2012年 / 44卷 / 15期
关键词：
amination; hydrogenation; green chemistry; benzylation; palladium; PROTECTING GROUP REMOVAL; ALDEHYDES; REACTOR; AMINES; OPTIMIZATION; KETONES;
D O I：
10.1055/s-0032-1316550
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A benzylpiperazine was prepared directly from the corresponding benzaldehyde and piperazine on a continuous-flow hydrogenation apparatus. The synthesis was protecting group free, safe, and environmentally friendly. Large-scale synthesis under flow hydrogenation conditions was also demonstrated.
引用
收藏
页码：2469 / 2473
页数：5
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