Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine

被引：22

作者：

Liu, Jing ^{[1
]}

Fitzgerald, Anne E. ^{[1
]}

Mani, Neelakandha S. ^{[1
]}

机构：

[1] Janssen Res & Dev LLC, San Diego, CA 92121 USA

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 15期

关键词：

amination; hydrogenation; green chemistry; benzylation; palladium; PROTECTING GROUP REMOVAL; ALDEHYDES; REACTOR; AMINES; OPTIMIZATION; KETONES;

D O I：

10.1055/s-0032-1316550

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A benzylpiperazine was prepared directly from the corresponding benzaldehyde and piperazine on a continuous-flow hydrogenation apparatus. The synthesis was protecting group free, safe, and environmentally friendly. Large-scale synthesis under flow hydrogenation conditions was also demonstrated.

引用

页码：2469 / 2473

页数：5

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