Highly diastereoselective and enantioselective direct Michael addition of phthalide derivatives to nitroolefins

被引：39

作者：

Luo, Jie ^{[1
,2
]}

Wang, Haifei ^{[3
]}

Zhong, Fangrui ^{[1
,2
]}

Kwiatkowski, Jacek ^{[1
,2
]}

Xu, Li-Wen ^{[4
]}

Lu, Yixin ^{[1
,2
,4
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Inst Life Sci, Singapore 117543, Singapore

[2] Natl Univ Singapore, Med Chem Program, Inst Life Sci, Singapore 117543, Singapore

[3] Hunan Univ Technol, Changsha, Hunan, Peoples R China

[4] Hangzhou Normal Univ, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 310012, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 51期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; PHOSPHINES SYNTHESIS; MANNICH REACTION; FACILE ACCESS; CYCLOADDITION; ALKYLATION; CARBONATES; OXINDOLES; CATALYSTS;

D O I：

10.1039/c3cc42187b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first asymmetric Michael addition of 3-substituted phthalides to nitroolefins promoted by amino acid-incorporating multifunctional catalysts has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in high yields, and in a highly diastereoselective and enantioselective manner. Facile synthesis of a chiral bicyclic lactam has also been demonstrated.

引用

页码：5775 / 5777

页数：3

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