Palladium-Catalyzed Cascade Desulfitative Arylation of Acetylinic Oximes with Sodium Arylsulfinates

Herein described a highly efficient palladium-catalyzed cascade desulfitative arylation of acetylinic oximes and sodium arylsulfinates with oxygen as the sole oxidant to access structurally diverse 4-aryl isoxazoles. This catalytic system exhibits mild conditions, broad substrate scope, and operational simplicity. Notably, other easily available aryl source substrates were perfectly tolerated in this catalytic system, thus providing a promising application in synthetic and pharmaceutical chemistry.