Development of pH-responsive core-shell nanocarriers for delivery of therapeutic and diagnostic agents

被引：65
|
作者：
Xu, Shangjie [1 ]
Luo, Ying [1 ]
Graeser, Ralph [2 ]
Warnecke, Andre [2 ]
Kratz, Felix [2 ]
Hauff, Peter [3 ]
Licha, Kai [3 ]
Haag, Rainer [1 ]
机构：
[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
[2] Tumor Biol Ctr, D-79106 Freiburg, Germany
[3] Bayer Schering Pharma AG, Global Drug Discovery, D-13342 Berlin, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期
关键词：
Dendritic core-shell architectures; pH-labile linkers; Hyperbranched polyglycerol; Biocompatible polymers; Anticancer agent; Tumor diagnostic; In vitro cytotoxicity; Tumor targeting mouse model; DRUG-DELIVERY; DENDRIMERS; MICELLES; CHEMISTRY; POLYMERS; DYES;
D O I：
10.1016/j.bmcl.2008.01.043
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this paper new dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine. Acid-sensitive properties of the new nanocarriers and in vitro cytotoxicity of the doxorubicin-nanocarrier are presented as well as preliminary data regarding their toxicity and tumor targeting potential in nude mice. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1030 / 1034
页数：5
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