Development of pH-responsive core-shell nanocarriers for delivery of therapeutic and diagnostic agents

被引：65

作者：

Xu, Shangjie ^{[1
]}

Luo, Ying ^{[1
]}

Graeser, Ralph ^{[2
]}

Warnecke, Andre ^{[2
]}

Kratz, Felix ^{[2
]}

Hauff, Peter ^{[3
]}

Licha, Kai ^{[3
]}

Haag, Rainer ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

[2] Tumor Biol Ctr, D-79106 Freiburg, Germany

[3] Bayer Schering Pharma AG, Global Drug Discovery, D-13342 Berlin, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Dendritic core-shell architectures; pH-labile linkers; Hyperbranched polyglycerol; Biocompatible polymers; Anticancer agent; Tumor diagnostic; In vitro cytotoxicity; Tumor targeting mouse model; DRUG-DELIVERY; DENDRIMERS; MICELLES; CHEMISTRY; POLYMERS; DYES;

D O I：

10.1016/j.bmcl.2008.01.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this paper new dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine. Acid-sensitive properties of the new nanocarriers and in vitro cytotoxicity of the doxorubicin-nanocarrier are presented as well as preliminary data regarding their toxicity and tumor targeting potential in nude mice. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1030 / 1034

页数：5

共 50 条

[31] Development of pH-responsive nanocarriers using trimethylchitosans and methacrylic acid copolymer for siRNA delivery
Dehousse, V.
Garbacki, N.
Colige, A.
Evrard, B.
[J]. BIOMATERIALS, 2010, 31 (07) : 1839 - 1849
[32] pH-responsive hydrogels with dispersed hydrophobic nanoparticles for the delivery of hydrophobic therapeutic agents
Schoener, Cody A.
Hutson, Heather N.
Peppas, Nicholas A.
[J]. POLYMER INTERNATIONAL, 2012, 61 (06) : 874 - 879
[33] pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents
Karimi, Mahdi
Eslami, Masoud
Sahandi-Zangabad, Parham
Mirab, Fereshteh
Farajisafiloo, Negar
Shafaei, Zahra
Ghosh, Deepanjan
Bozorgomid, Mahnaz
Dashkhaneh, Fariba
Hamblin, Michael R.
[J]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2016, 8 (05) : 696 - 716
[34] Ferrocene-functionalized magnetic core-shell nanoparticles based on hydrosilylation reaction for pH-responsive doxorubicin delivery system
Mohammadzadeh, Ali
Javanbakht, Siamak
Mohammadi, Reza
Kazeminava, Fahimeh
[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2024, 703
[35] Core-shell particles having silica cores and pH-responsive poly(vinylpyridine) shells
Atkin, R
Bradley, M
Vincent, B
[J]. SOFT MATTER, 2005, 1 (02) : 160 - 165
[36] Patterned dual pH-responsive core-shell hydrogels with controllable swelling kinetics and volumes
Plunkett, KN
Moore, JS
[J]. LANGMUIR, 2004, 20 (16) : 6535 - 6537
[37] Dual pH-Responsive Polymer Nanogels with a Core-Shell Structure for Improved Cell Association
Sui, Haiyan
Gao, Zhiliang
Guo, Jianman
Wang, Yitong
Yuan, Jin
Hao, Jingcheng
Dong, Shuli
Cui, Jiwei
[J]. LANGMUIR, 2019, 35 (51) : 16869 - 16875
[38] Self-Healing Coatings Containing Core-Shell Nanofibers with pH-Responsive Performance
Wang, Qi
Wang, Wei
Ji, Xiaohong
Hao, Xiangping
Ma, Chengcheng
Hao, Wei
Li, Xinglinmao
Chen, Shougang
[J]. ACS APPLIED MATERIALS & INTERFACES, 2021, 13 (02) : 3139 - 3152
[39] Programmed pH-responsive core-shell nanoparticles for precisely targeted therapy of ulcerative colitis
Zhang, Guangshuai
Han, Wen
Zhao, Peixu
Wang, Zijun
Li, Mo
Sui, Xiaofan
Liu, Yanhua
Tian, Baocheng
He, Zhonggui
Fu, Qiang
[J]. NANOSCALE, 2023, 15 (04) : 1937 - 1946
[40] pH-responsive core-shell nanogels induce in situ antigen production for cancer treatment
Fan, Ting
Ye, Wenping
Zhao, Pengxuan
Zhou, Weixin
Chen, Yan
He, Chuanchuan
Zhang, Xiaojuan
Yan, Ruicong
Chen, Chen
Luo, Jun
Yang, Tan
Ma, Xiang
Xiang, Guangya
Lu, Yao
[J]. CHEMICAL ENGINEERING JOURNAL, 2021, 426

← 1 2 3 4 5 →