Development of Core-Shell Structures Capable of pH-Responsive Release of Encapsulated Compounds

Currently, the development of drug delivery systems is an important trend in modern biomedicine. During the last five years, a tendency is observed to complicate the developed carriers with the production of complex multicomponent carriers in order to improve the targeting and selectivity of their action. For this purpose, various properties characteristic for particular sites of a body are used, thus making it possible to specify the action of the carriers. One of the used factors is the medium pH, which is strictly regulated by an organism and is constant in a particular site of it. In this work, we develop an approach to the formation of complex core-shell particles based on mesoporous calcium carbonate particles and AMS-6 silica particles. The loading capacity of the obtained complex particles with respect to TRITC-BSA model dye and the kinetics of its release from them are studied. The carriers obtained in the work are promising to be used as drug carriers with pH-dependent release kinetics of encapsulated drugs.