Biological properties and chemical composition of essential oil from Nectandra megapotamica (Spreng.) Mez. leaves (Lauraceae)

被引：5

作者：

Almeida, Karoliny C. R. ^{[1
]}

Silva, Bruna B. ^{[1
]}

Alves, Cassia C. F. ^{[2
]}

Vieira, Tatiana M. ^{[3
]}

Crotti, Antonio E. M. ^{[3
]}

Souza, Joao M. ^{[4
]}

Martins, Carlos H. G. ^{[4
]}

Ribeiro, Arthur B. ^{[4
]}

Squarisi, Iara S. ^{[4
]}

Tavares, Denise C. ^{[4
]}

Bernabe, Laura dos S. ^{[4
]}

Magalhaes, Lizandra G. ^{[4
]}

Miranda, Mayker L. D. ^{[5
]}

机构：

[1] Inst Fed Educ Ciencia & Tecnol Sul Minas Gerais, Pouso Alegre, MG, Brazil

[2] Inst Fed Educ Ciencia & Tecnol Goiano, Rio Verde, Go, Brazil

[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ribeirao Preto, SP, Brazil

[4] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP, Brazil

[5] Inst Fed Educ Ciencia & Tecnol Triangulo Mineiro, Uberlandia, MG, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 21期

关键词：

Nectandra megapotamica; essential oil; alpha-bisabolol; antibacterial activity; antileishmanial activity; antiproliferative activity;

D O I：

10.1080/14786419.2019.1608539

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Nectandra megapotamica is a tree species that naturally occurs in the Atlantic Forest, Brazil. This paper aims to investigate the chemical composition and in vitro antibacterial, antileishmanial and antiproliferative activities of essential oil from N. megapotamica leaves (NM-EO). It displayed high antibacterial activity against Streptococcus mutans, S. sobrinus, Prevotella nigrescens and Bacteroides fragilis. NM-EO also exhibited high antileishmanial activity against promastigote forms of Leishmania amazonensis. Its antiproliferative activity was evaluated against the following cells: GM07429A (normal cell), MCF-7 (human breast adenocarcinoma), HeLa (human cervical adenocarcinoma) and M059J (human glioblastoma). Its major components, which were determined by GC-FID and GC-MS, were alpha-bisabolol (13.7%), bicyclogermacrene (10.9%), (E,E)-farnesene (10.6%), Z-caryophyllene (9.5%) and (E)-beta-farnesene (7.0%). These results suggest that N. megapotamica, a Brazilian plant, shows initial evidence of a new and alternative source of substances of medicinal interest. [GRAPHICS] .

引用

页码：3149 / 3153

页数：5

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