Synthesis of Repaglinide Congeners

被引：3

作者：

Sundaram, Dhanraj T. S. S. ^{[1
,2
]}

Mitra, Jayati ^{[1
]}

Rajesh, C. ^{[1
]}

Islam, Aminul ^{[1
]}

Prabahar, Koilpillai Joseph ^{[1
]}

Rao, Battula Venkateswara ^{[2
]}

Douglas, Sanasi Paul ^{[2
]}

机构：

[1] Aurobindo Pharma Ltd, APL Res Ctr 2, Chem Res & Dev, Indrakaran V 502329, Andhra Pradesh, India

[2] Andhra Univ, Coll Engn A, Dept Chem Engn, Visakhapatnam, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 18期

关键词：

Benzyl repaglinide; hypoglycemic agent; impurity; N-acetyl-L-glutamic acid; repaglinide isomer; ACID;

D O I：

10.1080/00397911.2015.1064139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report describes a synthesis of two potent impurities of repaglinide, benzyl repaglinide 1 and repaglinide isomer 2, from commercially available raw materials: 2-fluoro benzonitrile, (S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butylamine (5), and 3-ethoxy-[4-(ethoxycarbonyl)phenyl]acetic acid (7). These impurities are the crucial components in determining the quality of the drug substance, repaglinide, during its manufacturing.

引用

页码：2092 / 2098

页数：7

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