Synthesis of Repaglinide Congeners

被引：3
|
作者：
Sundaram, Dhanraj T. S. S. [1 ,2 ]
Mitra, Jayati [1 ]
Rajesh, C. [1 ]
Islam, Aminul [1 ]
Prabahar, Koilpillai Joseph [1 ]
Rao, Battula Venkateswara [2 ]
Douglas, Sanasi Paul [2 ]
机构：
[1] Aurobindo Pharma Ltd, APL Res Ctr 2, Chem Res & Dev, Indrakaran V 502329, Andhra Pradesh, India
[2] Andhra Univ, Coll Engn A, Dept Chem Engn, Visakhapatnam, Andhra Pradesh, India
来源：
SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 18期
关键词：
Benzyl repaglinide; hypoglycemic agent; impurity; N-acetyl-L-glutamic acid; repaglinide isomer; ACID;
D O I：
10.1080/00397911.2015.1064139
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This report describes a synthesis of two potent impurities of repaglinide, benzyl repaglinide 1 and repaglinide isomer 2, from commercially available raw materials: 2-fluoro benzonitrile, (S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butylamine (5), and 3-ethoxy-[4-(ethoxycarbonyl)phenyl]acetic acid (7). These impurities are the crucial components in determining the quality of the drug substance, repaglinide, during its manufacturing.
引用
收藏
页码：2092 / 2098
页数：7
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