Effects of a novel inverse agonist selective for alpha5 GABAA receptors on spatial memory: comparison with the standard non-selective inverse agonist DMCM

被引:0
|
作者
Samardzic, J. [1 ]
Savic, M. M. [2 ]
Clayton, T. [3 ]
Rallapalli, S. [3 ]
Obradovic, D. I. [1 ]
Joksimovic, S. M. [4 ]
Sieghart, W. [5 ]
Cook, J. M. [3 ]
机构
[1] Univ Belgrade, Fac Med, Dept Pharmacol, Belgrade, Serbia
[2] Univ Belgrade, Fac Pharm, Dept Pharmacol, Belgrade, Serbia
[3] Univ Wisconsin, Dept Chem & Biochem, Milwaukee, WI 53201 USA
[4] Med & Med Devices Agcy Serbia, Pharmacol Lab, Belgrade, Serbia
[5] Med Univ Vienna, Ctr Brain Res, Vienna, Austria
关键词
D O I
10.1016/S0924-977X(08)70377-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:S285 / S285
页数:1
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共 44 条
  • [21] AM833 is a novel agonist of calcitonin family G protein-coupled receptors: pharmacological comparison to six selective and non-selective agonists
    Fletcher, Madeleine M.
    Keov, Peter
    Truong, Tin T.
    Mennen, Grace
    Hick, Caroline A.
    Zhao, Peishen
    Furness, Sebastian G. B.
    Kruse, Thomas
    Clausen, Trine R.
    Wootten, Denise
    Sexton, Patrick M.
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 377 (03): : 417 - 440
  • [22] Occupancy of human brain GABAA receptors by the novel α5 subtype-selective benzodiazepine site inverse agonist α5IA as measured using [11C]flumazenil PET imaging
    Eng, W.
    Atack, J. R.
    Bergstrom, M.
    Sanabria, S.
    Appel, L.
    Dawson, G. R.
    Sciberras, D.
    Hargreaves, R. J.
    Langstrom, B.
    Burns, H. D.
    [J]. NEUROPHARMACOLOGY, 2010, 59 (7-8) : 635 - 639
  • [23] A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxiety
    Bailey, J. E.
    Papadopoulos, A.
    Seddon, K.
    Nutt, D. J.
    [J]. JOURNAL OF PSYCHOPHARMACOLOGY, 2009, 23 (02) : 117 - 122
  • [24] Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats
    Yamada, J
    Sugimoto, Y
    Noma, T
    Yoshikawa, T
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 359 (01) : 81 - 86
  • [25] Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABAA inverse agonist
    Duchon, Arnaud
    Gruart, Agnes
    Albac, Christelle
    Delatour, Benoit
    Zorrilla de San Martin, Javier
    Delgado-Garcia, Jose Maria
    Herault, Yann
    Potier, Marie-Claude
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2020, 177 (05) : 1106 - 1118
  • [26] Pharmacokinetic and pharmacodynamic effects of the selective 5HT2A inverse agonist APD125 in healthy adults
    Luthringer, R.
    Prosser, W.
    Arnal, M.
    Martin, M.
    Staner, C.
    Shanahan, W.
    Staner, L.
    [J]. SLEEP, 2006, 29 : A39 - A39
  • [27] Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: The approximated activation of receptor subtypes may explain behavioral effects
    Obradovic, Aleksandar Lj.
    Joksimovic, Srdan
    Poe, Michael M.
    Ramerstorfer, Joachim
    Varagic, Zdravko
    Namjoshi, Ojas
    Batinic, Bojan
    Radulovic, Tamara
    Markovic, Bojan
    Roth, Brian L.
    Sieghart, Werner
    Cook, James M.
    Savic, Miroslav M.
    [J]. BRAIN RESEARCH, 2014, 1554 : 36 - 48
  • [28] Effects of PWZ-029, an α5GABAA receptor inverse agonist, on scopolamine-induced spatial learning deficits in the water maze
    Joksimovic, S. M.
    Timic, T.
    Radulovic, T.
    Rallapalli, S.
    Milinkovic, M. M.
    Divljakovic, J. M.
    Batinic, B.
    Cook, J. M.
    Savic, M. M.
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2012, 22 : S190 - S191
  • [29] A COMPARISON OF CARDIOVASCULAR AND SMOOTH-MUSCLE EFFECTS OF 5-HYDROXYTRYPTAMINE AND 5-CARBOXAMIDOTRYPTAMINE, A SELECTIVE AGONIST OF 5-HT1 RECEPTORS
    SAXENA, PR
    LAWANG, A
    [J]. ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, 1985, 277 (02): : 235 - 252
  • [30] Synthesis and biological evaluation of the selective inverse agonist PWZ-029 for alpha 5 Bzr/GABAaergic receptor subtypes: This ligand enhances cognition in rhesus monkeys
    Rallapalli, Sundari K.
    Moran, Casey
    Rowlett, James K.
    Cook, James M.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240