Effects of a novel inverse agonist selective for alpha5 GABAA receptors on spatial memory: comparison with the standard non-selective inverse agonist DMCM

被引:0
|
作者
Samardzic, J. [1 ]
Savic, M. M. [2 ]
Clayton, T. [3 ]
Rallapalli, S. [3 ]
Obradovic, D. I. [1 ]
Joksimovic, S. M. [4 ]
Sieghart, W. [5 ]
Cook, J. M. [3 ]
机构
[1] Univ Belgrade, Fac Med, Dept Pharmacol, Belgrade, Serbia
[2] Univ Belgrade, Fac Pharm, Dept Pharmacol, Belgrade, Serbia
[3] Univ Wisconsin, Dept Chem & Biochem, Milwaukee, WI 53201 USA
[4] Med & Med Devices Agcy Serbia, Pharmacol Lab, Belgrade, Serbia
[5] Med Univ Vienna, Ctr Brain Res, Vienna, Austria
关键词
D O I
10.1016/S0924-977X(08)70377-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:S285 / S285
页数:1
相关论文
共 44 条
  • [1] RY-023, an inverse agonist at alpha5 GABAA receptors: the influence on spatial memory and spontaneous locomotor activity
    Milinkovic, M. M.
    Savic, M. M.
    Rallapalli, S.
    Samardzic, J.
    Van Linn, M.
    Ugresic, N.
    Cook, J. M.
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 : S284 - S284
  • [2] An inverse agonist selective for α5 subunit-containing GABAA receptors enhances cognition
    Dawson, GR
    Maubach, KA
    Collinson, N
    Cobain, M
    Everitt, BJ
    MacLeod, AM
    Choudhury, HI
    McDonald, LM
    Pillai, G
    Rycroft, W
    Smith, AJ
    Sternfeld, F
    Tattersall, FD
    Wafford, KA
    Reynolds, DS
    Seabrook, GR
    Atack, JR
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 316 (03): : 1335 - 1345
  • [3] Acute effects of an inverse agonist selective for α5 GABAA receptors on rat behaviour in the forced swim test
    Samardzic, J.
    Batinic, B.
    Biawat, P.
    Obradovic, D. I.
    Cook, J. M.
    Savic, M. M.
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2012, 22 : S187 - S188
  • [4] Identification of a novel, selective GABAA α5 receptor inverse agonist which enhances cognition
    Chambers, MS
    Atack, JR
    Broughton, HB
    Collinson, N
    Cook, S
    Dawson, GR
    Hobbs, SC
    Marshall, G
    Maubach, KA
    Pillai, GV
    Reeve, AJ
    MacLeod, AM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (11) : 2227 - 2240
  • [5] REVERSAL OF ALCOHOL-INDUCED COGNITIVE DEFICITS BY AN INVERSE AGONIST SELECTIVE FOR α5GABAA RECEPTORS
    Chandler, C.
    Overton, J.
    Taylor, I.
    Pareek, T.
    Reeves-Darby, J.
    Ruedi-Bettschen, D.
    Platt, D.
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2018, 42 : 94A - 94A
  • [6] Selective GABAA α5 benzodiazepine inverse agonist antagonizes the neurobehavioral actions of alcohol
    Cook, JB
    Foster, KL
    Eiler, WJA
    McKay, PF
    Woods, J
    Harvey, SC
    Garcia, M
    Grey, C
    McCane, S
    Mason, D
    Cummings, R
    Li, XY
    Cook, JM
    June, HL
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2005, 29 (08) : 1390 - 1401
  • [7] Role of GABAA α5-containing receptors in ethanol reward:: The effects of targeted gene deletion, and a selective inverse agonist
    Stephens, DN
    Pistovcakova, J
    Worthing, L
    Atack, JR
    Dawson, GR
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 526 (1-3) : 240 - 250
  • [8] Anxiogenic properties of an inverse agonist selective for α3 subunit-containing GABAA receptors
    Atack, JR
    Hutson, PH
    Collinson, N
    Marshall, G
    Bentley, G
    Moyes, C
    Cook, SM
    Collins, I
    Wafford, K
    McKernan, RM
    Dawson, GR
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (03) : 357 - 366
  • [9] A non convulsant alpha5 selective GABA-A inverse agonist restores cognitive deficits in a mouse model of Down syndrome
    Delatour, B.
    Braudeau, J.
    Duchon, A.
    Dauphinot, L.
    Dodd, R. H.
    Herault, Y.
    Potier, M. C.
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2013, 23 : S136 - S137
  • [10] An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA α5 receptors with cognition enhancing properties
    Chambers, MS
    Atack, JR
    Carling, RW
    Collinson, N
    Cook, SM
    Dawson, GR
    Ferris, P
    Hobbs, SC
    O'Connor, D
    Marshall, G
    Rycroft, W
    MacLeod, AM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (24) : 5829 - 5832