Regulation of phenotypic transitions in the fungal pathogen Candida albicans

被引：132
|
作者：
Huang, Guanghua [1 ]
机构：
[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China
来源：
VIRULENCE | 2012年 / 3卷 / 03期
关键词：
Candida albicans; phenotypic transitions; white-opaque switching; cAMP-PKA pathway; filamentous development; ACTIVATED PROTEIN-KINASE; WHITE-OPAQUE TRANSITION; ALS GENE FAMILY; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTOR; FILAMENTOUS GROWTH; HYPHAL DEVELOPMENT; CELL-WALL; BIOFILM FORMATION; ADENYLYL-CYCLASE;
D O I：
10.4161/viru.20010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The human commensal fungus Candida albicans can cause not only superficial infections, but also life-threatening disease in immunocompromised individuals. C. albicans can grow in several morphological forms. The ability to switch between different phenotypic forms has been thought to contribute to its virulence. The yeast-filamentous growth transition and white-opaque switching represent two typical morphological switching systems, which have been intensively studied in C. albicans. The interplay between environmental factors and genes determines the morphology of C. albicans. This review focuses on the regulation of phenotypic changes in this pathogenic organism by external environmental cues and internal genes.
引用
收藏
页码：251 / 261
页数：11
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