Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population

被引：29
|
作者：
Venkatesh, Shyamala K. [1 ]
Siddaiah, Anand [2 ]
Padakannaya, Prakash [2 ]
Ramachandra, Nallur B. [1 ]
机构：
[1] Univ Mysore, Dept Studies Zool, Genet & Genom Lab, Mysore 570006, Karnataka, India
[2] Univ Mysore, Dept Studies Psychol, Mysore 570006, Karnataka, India
来源：
JOURNAL OF HUMAN GENETICS | 2013年 / 58卷 / 08期
关键词：
case-control; developmental dyslexia; KIAA0319 and DCDC2; MassARRAY; SNPs; QUANTITATIVE-TRAIT LOCUS; CHROMOSOME 6P INFLUENCES; SUSCEPTIBILITY GENE; READING-DISABILITY; ASSOCIATION; FAMILIES; LINKAGE; COHORT; SKILLS;
D O I：
10.1038/jhg.2013.46
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Developmental dyslexia (DD) is a heritable, complex genetic disorder associated with impairment in reading and writing skills despite having normal intellectual ability and appropriate educational opportunities. Chromosome 6p23-21.3 at DYX2 locus has showed the most consistent evidence of linkage for DD and two susceptible genes KIAA0319 and DCDC2 for DD at DYX2 locus showed significant association. Specific candidate gene-association studies have identified variants, risk haplotypes and microsatellites of KIAA0319 and DCDC2 correlated with wide range of reading-related traits. In this study, we used a case-control approach for analyzing single-nucleotide polymorphisms (SNPs) in KIAA0319 and DCDC2. Our study demonstrated the association of DD with SNP rs4504469 of KIAA0319 and not with any SNPs of DCDC2.
引用
收藏
页码：531 / 538
页数：8
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