Meta-analysis of the Association Between DCDC2 Polymorphisms and Risk of Dyslexia

被引：29
|
作者：
Zhong, Rong [1 ,2 ,3 ]
Yang, Beifang [1 ,2 ]
Tang, Hui [3 ]
Zou, Li [1 ,2 ]
Song, Ranran [1 ,2 ]
Zhu, Ling-Qiang [3 ]
Miao, Xiaoping [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Dept Epidemiol & Biostat, Wuhan 430074, Peoples R China
[2] Huazhong Univ Sci & Technol, Minist Educ Key Lab Environm & Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan 430074, Peoples R China
[3] Huazhong Univ Sci & Technol, Dept Pathophysiol, Key Lab Neurol Dis, Educ Minist,Tongji Med Coll, Wuhan 430074, Peoples R China
来源：
MOLECULAR NEUROBIOLOGY | 2013年 / 47卷 / 01期
关键词：
DCDC2; Polymorphisms; Developmental dyslexia; Meta-analysis; SUSCEPTIBILITY GENE; READING-DISABILITY; KIAA0319; PHOSPHORYLATION; DOUBLECORTIN; CHILDREN;
D O I：
10.1007/s12035-012-8381-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Developmental dyslexia (DD) is a highly heritable neurological disorder that is prevalent in school-aged children. The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. However, the associations between DCDC2 genetic variations and dyslexia have yielded inconclusive results. Clarifying the effects of DCDC2 polymorphisms on dyslexia risk will advance not only elucidation of the role of DCDC2 in the brain development but also development of possible therapeutic approach for dyslexia. In this review, we summarized the ongoing association studies concerning DCDC2 polymorphisms and dyslexia risk by using meta-analysis and revealed that DCDC2 rs807701 might contribute significantly to dyslexia risk.
引用
收藏
页码：435 / 442
页数：8
相关论文
共 50 条
  • [1] Meta-analysis of the Association Between DCDC2 Polymorphisms and Risk of Dyslexia
    Rong Zhong
    Beifang Yang
    Hui Tang
    Li Zou
    Ranran Song
    Ling-Qiang Zhu
    Xiaoping Miao
    [J]. Molecular Neurobiology, 2013, 47 : 435 - 442
  • [2] Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese
    Zuo Peng-xiang
    Wu Han-rong
    Li Zeng-chun
    Cao Xu-dong
    Pang Li-juan
    Yang Lan
    Liu Fan
    Zhao Feng
    [J]. CHINESE MEDICAL JOURNAL, 2012, 125 (04) : 622 - 625
  • [3] Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese
    ZUO Peng-xiang
    [J]. 中华医学杂志(英文版), 2012, (04) : 622 - 625
  • [4] The DCDC2 deletion is not a risk factor for dyslexia
    T S Scerri
    E Macpherson
    A Martinelli
    W C Wa
    A P Monaco
    J Stein
    M Zheng
    C Suk-Han Ho
    C McBride
    M Snowling
    C Hulme
    M E Hayiou-Thomas
    M M Y Waye
    J B Talcott
    S Paracchini
    [J]. Translational Psychiatry, 2017, 7 : e1182 - e1182
  • [5] The DCDC2 deletion is not a risk factor for dyslexia
    Scerri, T. S.
    Macpherson, E.
    Martinelli, A.
    Wa, W. C.
    Monaco, A. P.
    Stein, J.
    Zheng, M.
    Ho, C. Suk-Han
    McBride, C.
    Snowling, M.
    Hulme, C.
    Hayiou-Thomas, M. E.
    Waye, M. M. Y.
    Talcott, J. B.
    Paracchini, S.
    [J]. TRANSLATIONAL PSYCHIATRY, 2017, 7 : e1182 - e1182
  • [6] Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
    Penelope A Lind
    Michelle Luciano
    Margaret J Wright
    Grant W Montgomery
    Nicholas G Martin
    Timothy C Bates
    [J]. European Journal of Human Genetics, 2010, 18 : 668 - 673
  • [7] Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
    Lind, Penelope A.
    Luciano, Michelle
    Wright, Margaret J.
    Montgomery, Grant W.
    Martin, Nicholas G.
    Bates, Timothy C.
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2010, 18 (06) : 668 - 673
  • [8] Polymorphisms in DCDC2 and S100B associate with developmental dyslexia
    Hans Matsson
    Mikael Huss
    Helena Persson
    Elisabet Einarsdottir
    Ettore Tiraboschi
    Jaana Nopola-Hemmi
    Johannes Schumacher
    Nina Neuhoff
    Andreas Warnke
    Heikki Lyytinen
    Gert Schulte-Körne
    Markus M Nöthen
    Paavo HT Leppänen
    Myriam Peyrard-Janvid
    Juha Kere
    [J]. Journal of Human Genetics, 2015, 60 : 399 - 401
  • [9] DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children
    Chen, Yun
    Zhao, Hua
    Zhang, Yi-xin
    Zuo, Peng-xiang
    [J]. NEURAL REGENERATION RESEARCH, 2017, 12 (02) : 259 - 266
  • [10] DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children
    Yun Chen
    Hua Zhao
    Yi-xin Zhang
    Peng-xiang Zuo
    [J]. Neural Regeneration Research, 2017, 12 (02) : 259 - 266
12345