Antifungal Activities of Human Beta-Defensins HBD-1 to HBD-3 and Their C-Terminal Analogs Phd1 to Phd3

被引：80
|
作者：
Krishnakumari, Viswanatha [1 ]
Rangaraj, Nandini [1 ]
Nagaraj, Ramakrishnan [1 ]
机构：
[1] CSIR, Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 01期
关键词：
ANTIMICROBIAL PEPTIDES; ANTIBACTERIAL ACTIVITIES; HUMAN BETA-DEFENSIN-3; SALIVARY-GLANDS; MAMMALIAN DEFENSINS; DISULFIDE; EXPRESSION; CANDIDA; CONFORMATIONS; BRIDGES;
D O I：
10.1128/AAC.00470-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD- 1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD- 1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.
引用
收藏
页码：256 / 260
页数：5
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