Antifungal Activities of Human Beta-Defensins HBD-1 to HBD-3 and Their C-Terminal Analogs Phd1 to Phd3

被引：80

作者：

Krishnakumari, Viswanatha ^{[1
]}

Rangaraj, Nandini ^{[1
]}

Nagaraj, Ramakrishnan ^{[1
]}

机构：

[1] CSIR, Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 01期

关键词：

ANTIMICROBIAL PEPTIDES; ANTIBACTERIAL ACTIVITIES; HUMAN BETA-DEFENSIN-3; SALIVARY-GLANDS; MAMMALIAN DEFENSINS; DISULFIDE; EXPRESSION; CANDIDA; CONFORMATIONS; BRIDGES;

D O I：

10.1128/AAC.00470-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD- 1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD- 1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.

引用

页码：256 / 260

页数：5

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